In June 2012, it was announced that Paramount Pictures was developing the film Monster Problems, with Shawn Levy producing, based on a spec script by Brian Duffield. It was described as a post-apocalyptic road movie in the vein of Mad Max and Zombieland with a John Hughes-esque love story.

In October 2018, it was announced that Dylan O’Brien was in talks to star, and that Michael Matthews was directing the film. By March 2019, Michael Rooker and Ariana Greenblatt had joined O’Brien. In April 2019, it was announced that Jessica Henwick had joined the cast. Also in April, Australian actor Dan Ewing joined the film in a supporting role. Principal photography started on the Gold Coast on March 25, 2019, and ended in May 2019.